The Superhero Universe is a famous place for archenemy relationships to occur. Even though heroes fight for the saftey of civilians against many powerful foes in their rogue galleries, only one stands out the most.
- Superman's archenemy is Lex Luthor; a criminal genius who builds many deadly kryptonite weapons.
- Batman's archenemy is the Joker; Gotham's clown prince of crime and chaos.
- Wonder Woman's archenemy is Cheetah; a villainess who fights with savage claws.
- Green Lantern's archenemy is Sinestro; an ex-mentor who turned to the yellow light of fear.
- The Flash's archenemy is Professor Zoom; a reverse-Flash who can go at amazing speeds.
- Hawkman's archenemy is Hath-Set; an Egyptian ruler who killed the original Hawkman and Hawkgirl.
- Martian Manhunter's archenemy is Malefic; his sick twisted brother who is immune to fire.
- Plastic Man's archenemy is Dr. Dome; a scientist with a dome hat.
- The Atom's archenemy is Chronos; a time traveler with the ability to manipulate history.
- Captain Marvel's archenemy is Dr. Sivana; a mad scientist who commits crime with his family.
- Green Arrow's archenemy is Merlyn; a rival archer.
- Blackhawk's archenemy is Killer Shark; a modern day pirate equipped with powerful submarines.
- The Watchmen's archenemy is Ozymandias; a former member that wants to save the entire world by destroying some of it.
- The Teen Titans' archenemy is Deathstroke; a mercenary with superhuman abilities.
- Jonah Hex's archenemy is Quentin Turnbull; an outlaw with a vengeance against Hex.
- V's archenemy is Adam Susan; a dictator who does not let people live freely.
- The Justice League's archenemy is Darkseid; the supreme monarch of the planet Apokolips, he seeks to control all living things with the Anti-Life Equation.
- Aquaman's archenemy is Black Manta; a scarred villain with dreams of ruling the sea.
- Firestorm's archenemy is Multiplex; a supervillain that can split into multiple clones.
- Blue Beetle's archenemy is Masked Marauder; a masked gunman with a wrecked reputation.
- Nightwing's archenemy is Blockbuster; the crime lord of Bludhaven.
- Spider Jerusalem's archenemy is Gary Callaham A.k.a. "Smiler"; A corrupt President.
- The Sandman, aka Dream's archenemy is his sibling Desire, who can make someone fall in love with him/her, as he/she is the embodiment of Desire.
- John Constantine, the Hellblazer's archenemy is the First of the Fallen, who is the true first angel to fall into Hell.
- Spiderman's archenemy is the Green Goblin; a masked criminal with insane tendencies.
- Hulk's archenemy is The Leader; an ambitious criminal who got irratiated with Gamma rays that caused him getting infinite knowledge .
- Professor X and X-Men's archenemy is Magneto and his Brotherhood of Mutants; a villain who has the ability to manipulate magnetic objects who wants to kill all non-mutants so the Homo Superior rule the Earth.
- Thor's archenemy is Loki; his brother who causes mischief and terror everywhere he goes.
- Captain America's archenemy is Red Skull; a terrorist and an ex-nazi with the same abilities and physical durability as the Captain.
- Iron Man's archenemy is Mandarin; a martial artist with magical abilities.
- The Fantastic 4's archenemy is Dr. Doom; a supervillain with pure genius and total knowledge and control of magic, technology and science. He is the emperor of his country "Latveria".
- Ghost Rider's archenemy is Mephisto; Marvel's Satan and once the boss of the Ghost Rider.
- Blade's archenemy is Deacon Frost; a vampire who killed Blade's mother.
- Luke Cage's archenemy is Chemistro; a supervillain armed with an alchemy gun.
- Iron Fist's archenemy is Master Khan; an evil kung fu master.
- Punisher's archenemy is Jigsaw; a crime boss with stitches all over his face.
- Jessica Jones A.k.a. Knightress, Power Woman, Jewel's archenemy is Purple Man; a mind controller that kidnapped her years ago.
- US Archer's Archenemy is Highwayman; his brother who has sided with demons.
- Hawkeye's archenemy is Crossfire; an assassin with a cybernetic eye and ear.
- Moon Knight's archenemy is Bushman; a man with steel teeth.
- Deapool's archenemy is T-Ray; who claims to have the same identity as Deadpool.
- Darkhawk's archenemy is Evilhawk; an intergalactic crime lord.
- Nick Fury and S.H.I.E.L.D.'s archenemy is Baron von Strucker and HYDRA; a terrorist organization led by Baron von Strucker.
- Hercules' archenemy is Ares; the God of War.
- Namor the Sub-Mariner's archenemy is Attuma; a rival Atlantean.
- War Machine's archenemy is The Advisor; a terrorist who can manipulate fire.
- She-Hulk's archenemy is Titania; a villainess with super strength.
- Wolverine's archenemy is Sabretooth; his mutant longtime rival.
- Hank Pym's archenemy is Egghead; a loathsome scientist who quickly became a nemesis to Hank Pym.
- The Sentry's archenemy is Void; a projection of his dark side.
- The Vision's archenemy is Ultron; a robot created by Hank Pym that wants to end all organic life forms.
- The Silver Surfer's archenemy is Thanos; an alien who wants to cause all forms of life destruction.
- Dr. Strange's archenemy is Dormammu; a mystical being who lives in another dimension.
- Daredevil's archenemy is Kingpin; the biggest mob boss of Hell's Kitchen.
- Black Panther's archenemy is Klaw; a physicist who has been transformed into solid sound who killed Black Panther's father.
- The Wasp's archenemy is The Human Top; a criminal who can turn into a tornado.
- Sgt. Fury and the Howling Commandos' archenemies are the Nazis; you gotta be kiddin' if ya want me to actually describe those fellas (Nick Fury-1963).
- The X-Factor's archenemies are the Acolytes; the first group of desperate mutants on the run from S.H.I.E.L.D.
- The Thing's archenemies are the Yancy Street Gang; gang of thugs that stain the Thing's name, but Grimm himself was once a member of it.
- Cable and the X-Force's archenemy is Mr. Sinister and the Marauders; mercenaries who assassinate other mutants, and act in unison as a commando strike-force to carry out acts of mass murder.
- Guardians of the Galaxy's archenemy is the the Matriarch and her Universal Church of Truth; The head of the Church was the Matriarch, object of its worship was Adam Warlock's evil self, the Magus. The Universal Church of Truth is a religious empire composed of diverse alien species from all across the universe.
- Ka-Zar's archenemy is Quor; An alien that crashed in the Savage Land. Using his knowledge and technology, he convinced a tribe of Reptile Men that he was to lead them.
- Red Raven's archenemy is Makkari; A villian that has the skill of absorbing energy and more.
- Zorro's archenemy is Montero; a power abuser.
- The Green Hornet's archenemy is Mr X; a mysterious criminal.
- Robocop's archenemy is ED-209; a rival robot with flaws.
- Hellboy's archenemy is Grigori Rasputin; the agent of the Ogdru Jahad.
- Judge Dredd's archenemy is Judge Death; leader of the Dark Judges.
- Spawn's archenemy is the Violator; a monstrous demon with dreams of Hell on Earth.
- The Shadow's archenemy is Shiwan Khan; a legendary warrior brought back from the dead. He is the last living descendant of Genghis Khan.He operates from the lost underground city of Xanadu, beneath the Sinkiang. He has access to the treasures of Kublai Khan and was trained by the Tibetan monks to use telepathic powers
- The Umbrella Academy's archenemy is the Temps Aeternalis; a group of highly trained assassins.
- Teenage Mutant Ninja Turtles' archenemy is Shredder; a high skilled warrior who wants to kill the TMNT's sensei, Splinter and take over the world with his Foot Clan.
- Kick-Ass' archenemy is Red Mist; a wannabe superhero(or better villain).
- Ben 10's archenemy is Vilgax; an alien overlord who wants the Omnitrix from Ben's wrist
- Gen Rex's archenemy is Van Kleiss; an E.V.O. scientist who hates and despises Providence
- Max Steel's archenemy is Miles Dredd; A scientist who was involved in an accident which fused a machine to his body that absorbs Turbo Energy
Lex Luthor by Jerry Siegel and Joe Shuster
Darkseid by Jack Kirby
The First of the Fallen by Garth Ennis and Will Simpson
The Joker by Bob Kane , Jerry Robinson and Bill Finger
Adam Susan by Alan Moore and David Lloyd
Sinestro by John Broome and Gil Kane
Professor Zoom by John Broome and Carmine Infantino
Cheetah by William Moulton Marston and H. G. Peter
Black Manta by Bob Haney and Nick Cardy
Dr. Sivana by Bill Parker and C. C. Beck
Malefic by John Ostrander and Tom Mandrake
Desire by Neil Gaiman and Mike Dringenberg
Deathstroke by Marv Wolfman and George Pérez
Merlyn by Mike Friedrich, Neal Adams and Dick Dillin
Dr. Dome by Gil Kane
Hath-Set by Gardner Fox and Dennis Neville
Ozymanidias by Alan Moore and Dave Gibbons
Chronos by Gardner Fox and Gil Kane
The Masked Marauder by Gary Friedrich and Ditko
Gary Callahan “The Smiler” by Warren Ellis and Darick Robertson
Killer Shark by Reed Crandall
Quentin Turnbull by Michael Fleisher and Tony DeZuniga
Multiplex by Gerry Conway and Al Milgrom
Blockbuster by Gardner Fox, Carmine Infantino
Magneto and the Brotherhood of Mutants by Stan Lee and Jack Kirby
Green Goblin by Stan Lee and Steve Ditko
Red Skull by Joe Simon, Jack Kirby and France Herron
Mandarin by Stan Lee and Don Heck
Dr. Doom by Stan Lee and Jack Kirby
The Leader by Stan Lee and Steve Ditko
The Kingpin by Stan Lee and John Romita, Sr
Loki “by” Stan Lee, Larry Lieber y Jack Kirby
Jigsaw by Len Wein and Ross Andru
Mephisto by Stan Lee and John Buscema
Thanos by Jim Starlin
Dormammu by Stan Lee and Steve Ditko
Attuma by Stan Lee and Jack Kirby
Master Khan by Stan Lee and Steve Ditko
Ultron by Roy Thomas and John Buscema
Klaw by Stan Lee and Jack Kirby
The Matriarch and the Universal Church of Truth by Jim Starlin
Baron von Strucker and HYDRA by Stan Lee and Jack Kirby
Titania by Jim Shooter and Mike Zeck
Sabretooth by Chris Claremont and John Byrne
Void by Paul Jenkins, Jae Lee and Rick Veitch
Ares “by” Stan Lee and Jack Kirby
Quor by Arnold Drake, Steve Parkhouse and George Tuska
Nazis “by” Stan Lee and Jack Kirby
The Acolytes by Chris Claremont and Jim Lee
The Human Top by Stan Lee and Jack Kirby
Mr. Sinister by Chris Claremont and Marc Silvestri
Marauders by Chris Claremont, John Romita Jr. And Dan Green
Evilhawk by Danny Fingeroth and Mike Manley
Highwayman by Erik Larsen and Chris Marrinan
Bushman by Doug Moench
Crossfire by Steven Grant and Jim Craig
Purple Man by Stan Lee and Joe Orlando
Egghead by Stan Lee, Larry Lieber and Jack Kirby
T-Ray by Joe Casey and John Paul Leon
The Advisor by Scott Benson and Gabriel Gecko
Chemistro by Steve Englehart and George Tuska
Deacon Frost by Marv Wolfman and Gene Colan
The Violator by Todd McFarlane
Judge Death by John Wagner and Brian Bolland
Grigori Rasputin by Mike Mignola and John Bryne
Shiwan Khan by Walter B. Gibson
Mr. X by (Unknown Data)
Red Mist by Mark Millar and John Romita, Jr.
Shredder by Kevin Eastman and Peter Laird
The Temp Aeternalis by Gerard Way and Gabriel Bá
Montero by Ian Rimmer and Mario Capaldi
Vilgax by Duncan Rouleau, Joe Casey, Joe Kelly and Steven T. Seagle
ED-209 by Paul Verhoeven and Craig Hayes
Van Kleiss by Duncan Rouleau, Joe Casey, Joe Kelly, And Steven T. Seagle
Miles Dredd by Matthew Drdek and Lloyd Goldfine